9 Positive Signs After Embryo Transfer

Positive Signs After Embryo Transfer

In-vitro Fertilization (IVF) has become a beacon of hope for couples struggling with infertility. Embryo transfer is a crucial component of this assisted reproductive technology (ART). This procedure involves placing a fertilized egg into the woman’s uterus, hoping it will implant and lead to a successful pregnancy.

The waiting period of approximately two weeks following the transfer, often called the “two-week wait,” is filled with anticipation. During this time, a multitude of physical symptoms may appear, causing hopeful parents to wonder if they indicate a positive outcome. This article will explore the various Positive Signs After Embryo Transfer that could suggest successful implantation.

Embryo Transfer in IVF: An Overview

Embryo transfer is the final stage in the IVF process. It involves the careful placement of one or more embryos into the woman’s uterus using a thin catheter. The decision on the number of embryos to transfer largely depends on the quality of the embryos, the woman’s age, and the couple’s preferences.


In some cases, if the embryos are of lower quality or if the woman is over 35 years old, a doctor may decide to transfer more than one embryo to enhance the chances of a successful pregnancy. However, it’s important to note that multiple pregnancies present their own set of risks to both the mother and the babies.

The Role of Embryo Transfer in IVF and ICSI

Intracytoplasmic sperm injection (ICSI) is another ART method that involves injecting a single sperm directly into an egg to achieve fertilization. Despite the differences in the initial stages of IVF and ICSI, the embryo transfer process remains the same across both treatments.

In both IVF and ICSI, the fertilized embryo is grown in a laboratory for a few days before being transferred into the woman’s uterus. After the transfer, the first indications of success typically present as cramps, nausea, and vomiting. However, it’s crucial to undergo reliable tests, such as blood and urine tests, to confirm pregnancy.

Timing of Pregnancy Tests After Embryo Transfer

While taking a pregnancy test immediately after the embryo transfer is tempting, waiting for approximately two weeks is recommended. This is because the placenta starts secreting the pregnancy hormone human chorionic gonadotropin (hCG) about 10 to 12 days post-transfer. Therefore, to avoid false results and unnecessary stress, it’s advisable to wait for this two-week period before taking a home pregnancy test or a beta blood test.

Deciphering the Positive Signs After Embryo Transfer

As part of the IVF or ICSI process, patients are typically required to take fertility medications containing estrogen and progesterone. These drugs can produce symptoms that closely resemble those of early pregnancy. Nevertheless, observing specific symptoms can hint at a successful embryo transfer, although a blood test is the most definitive way to confirm pregnancy.

Here are some symptoms that might indicate a positive outcome after embryo transfer:

Missed Menstrual Period

A missed menstrual period is often the first sign of pregnancy. Suppose your menstrual cycle is typically regular, and you’ve missed a period. In that case, it might be an indication of successful embryo transfer.

Light Bleeding or Spotting

Light bleeding or spotting about a week after the embryo transfer could be a sign of implantation, suggesting the embryo has successfully attached itself to the uterine lining. However, this symptom can also be caused by the progesterone injections administered during IVF treatments. Hence, light bleeding or spotting may or may not indicate successful implantation.

Breast Tenderness and Soreness

Breast tenderness and soreness, similar to what some women experience during their menstrual cycle, can be an early sign of pregnancy. However, the hormonal changes caused by fertility medications can also lead to these symptoms. Therefore, while breast tenderness might suggest a successful embryo transfer, it is not a definitive sign.

Cramping and Bloating

Mild cramping and bloating are common symptoms after an embryo transfer. While cramping is often associated with an impending menstrual period, it could also indicate successful implantation. On the other hand, bloating can occur as a side effect of the increased progesterone levels brought on by fertility medications or pregnancy.


Feeling unusually tired or fatigued could be a symptom of early pregnancy. The increased levels of progesterone in the body can cause fatigue. However, fertility drugs can also lead to this symptom, making it tricky to determine its cause.

Nausea and Vomiting

Morning sickness, characterized by nausea and vomiting, is a common pregnancy symptom. If you experience these symptoms, it may suggest that the embryo transfer was successful. However, these symptoms are also common side effects of fertility drugs, so it’s essential to consult with your doctor if they persist.

Increased Vaginal Discharge

An increase in vaginal discharge can be an early sign of pregnancy. However, this symptom can also result from the vaginal suppositories, gel, or tablets used during IVF treatments. Therefore, while increased discharge could indicate a successful embryo transfer, it is not a certain sign.

Frequent Urination

Frequent urination, especially at night, can be an early sign of pregnancy. The increased levels of hCG and progesterone during pregnancy can lead to this symptom. However, it could also indicate a urinary tract infection requiring immediate medical attention.

Sensation of Heaviness in the Lower Abdomen

Feeling a sensation of heaviness or pressure in the lower abdomen can be a sign of implantation. This symptom is often accompanied by bloating or swelling of the ovaries. However, it’s important to remember that fertility medications can also cause these symptoms.

What If There Are No Symptoms After Embryo Transfer?

Having no symptoms after an embryo transfer does not necessarily mean the procedure was unsuccessful. About 10 to 15% of patients who don’t experience any symptoms during the two-week wait still achieve a successful pregnancy and subsequent live birth. Therefore, the presence or absence of symptoms should not be used as a definitive indicator of the procedure’s success.

In conclusion, while certain symptoms can indicate a positive outcome after an embryo transfer, they are not definitive signs of successful implantation. A blood or home pregnancy test is the only surefire way to confirm pregnancy after an embryo transfer. Be patient during the two-week wait and consult your healthcare provider if you have any concerns.